Drug crystal fomu yekutsvaga uye kuenderana kwekuongorora

Online Raman inokurumidza kutarisisa kuwirirana kweakawanda mabheji ekugadzira neiyo crystalline fomu yeanoshanda emishonga zvinongedzo.

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Kutariswa kwepamhepo kunopa kukurumidza mhedzisiro yekutariswa kwekristaro kuyedzwa, inoenderera data inokurudzira maitiro ekuita uye magumo, ichipa optimization, mafambiro.

Mhando dzakasiyana dzekristaro dzemushonga mumwechete dzinogona kuratidza kusiyana kwakakura mukutaridzika, kunyungudika, kunyungudika, chiyero chekunyungudika, bioavailability, nezvimwewo, zvichikanganisa kugadzikana, bioavailability, uye kushanda kwemushonga.Naizvozvo, zvinodikanwa kusimbisa kuvepo kweiyo inotarirwa fomu yekristaro panguva yekugadzirwa kwezvinodhaka uye maitiro ekugadzira.

Mukugadzira mushonga mutsva, zvinodikanwa kutarisa munguva-chaiyo kuumbwa kwekristalline chikamu chemushonga mune synthesis reaction solution.Izvi zvinoitirwa kukwenenzvera maitiro uye kuona kuti chinonangwa chemushonga crystalline chikamu chakagadzirwa.Raman spectroscopy inogona kushandiswa in-situ monitoring, ichipa chaiyo-nguva yekuongorora yecrystalline chikamu chinoumbwa mumishonga synthesis reaction, kunyanya yakakodzera kuongororwa kwakadzama kwepolymorphic uye amorphous API-ine masisitimu.

Online Raman spectroscopy inofambisa kristaro chikamu chekuongorora kweakasiyana maitiro ekuita, sezvinoratidzwa nekambani yemishonga kuyedza kwemabhechi ekugadzira.Mhedzisiro yacho yakasimbisa kurongeka neiyo inoshanda mishonga yemishonga, ichiratidza tsvakiridzo yakabudirira.Pamberi pekugumira uchishandisa XRD uye zvimwe zviridzwa zverabhoritari zvakatungamira kune zvimhingamipinyi zvedata uye kutenderera kwakawedzerwa kwekusimudzira.Imwe nyaya yakasimbisa yakabudirira chaiyo-nguva kusiyanisa kwekristaro chikamu shanduko mumatanho matanhatu akasiyana, ichipa manzwisisiro ekukurumidza mune zvigadzirwa.

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Online Raman inokurumidza kuona iyo crystalline chikamu shanduko mhedzisiro pasi pemamiriro akasiyana ekuita.


Nguva yekutumira: Zvita-26-2023